Akụkọ

Gịnị kpatara ihe karịrị 300 ikpe nke nnukwu ịba ọcha n'anya nke amaghị etiology na ihe karịrị 20 mba na mpaghara gburugburu ụwa? Nnyocha ọhụrụ gosiri na ọ nwere ike jikọta ya na super antigen nke coronavirus ọhụrụ kpatara. E bipụtara nchoputa ndị a n'elu n'akwụkwọ akụkọ agụmakwụkwọ mba ụwa "Lancet Gastroenterology & Hepatology".

Ọmụmụ ihe ndị a kpọtụrụ aha n'elu egosila na ụmụaka bu ọrịa coronavirus ọhụrụ nwere ike iduga n'ịmepụta ebe nchekwa nje n'ime ahụ. Kpọmkwem, ọnụnọ coronavirus ọhụrụ na-adịgide adịgide na eriri afọ nke ụmụaka nwere ike iduga ntọhapụ nke protein viral ugboro ugboro na sel epithelial intestinal, na-ebute ịgbalite mgbochi. Enwere ike ịgbalite mgbakwasa ọrịa ahụ ugboro ugboro site na nnukwu antigen motif na protein spike nke coronavirus ọhụrụ, nke yiri staphylococcal enterotoxin B ma na-akpalite ịgbalite cell T sara mbara na enweghị nkọwa. Nke a super antigen-mediated gbalite nke mkpụrụ ndụ anaghị alụso ọrịa ọgụ etinyela aka na ọrịa inflammatory nke ọtụtụ sistemu (MIS-C).

Ihe a na-akpọ super antigen (SAg) bụ ụdị ihe nwere ike mee ka ọnụ ọgụgụ buru ibu nke clones T cell rụọ ọrụ ma mepụta nzaghachi mgbochi siri ike na-enwe naanị ntinye dị ala (≤10-9 M). Multisystem inflammatory syndrome na ụmụaka malitere inweta nlebara anya zuru ebe niile dị ka Eprel 2020. N'oge ahụ, ụwa ka abanyela n'ọrịa okpueze ọhụrụ, na ọtụtụ mba na-aga nke ọma na-akọ banyere "ọrịa iju ụmụaka", bụ nke metụtara ọrịa nje okpueze ọhụrụ. Ọtụtụ ndị ọrịa na-enweta mgbaàmà dị ka ahụ ọkụ, ọkụ ọkụ, ọgbụgbọ, ọzịza n'olu lymph, egbugbere ọnụ gbawara agbawa, na afọ ọsịsa, dị ka nke ọrịa Kawasaki, nke a makwaara dị ka ọrịa Kawasaki. Multisystem inflammatory syndrome na ụmụaka na-emekarị 2-6 izu mgbe ọhụrụ okpueze ọrịa, na afọ nke mmalite ụmụaka na-lekwasị n'etiti 3-10 afọ. Multisystem inflammatory syndrome na ụmụaka dị iche na ọrịa Kawasaki, ọrịa ahụ na-akawanye njọ n'ime ụmụaka ndị nyochara ihe dị mma maka COVID-19.

Ndị nyocha ahụ nyochara na nnukwu ịba ọcha n'anya na-adịbeghị anya nke amaghị ihe kpatara ụmụaka nwere ike bu ụzọ bute ọrịa coronavirus ọhụrụ, ụmụaka ahụ butere adenovirus mgbe nchekwa nje pụtara n'ime eriri afọ.

Ndị nchọpụta ahụ na-akọ banyere ọnọdụ yiri nke ahụ na nyocha nke òké: Adenovirus ọrịa na-ebute staphylococcal enterotoxin B-mediated toxic shock, na-eduga na imeju ọdịda na ọnwụ na ụmụ oke. Dabere na ọnọdụ dị ugbu a, a na-atụ aro nyocha COVID-19 na-aga n'ihu na stool ụmụaka nwere nnukwu ịba ọcha n'anya. Ọ bụrụ na achọpụtara ihe akaebe nke SARS-CoV-2 superantigen-mediated ịgbalite mgbochi ọrịa, a ga-atụle ọgwụgwọ immunomodulatory na ụmụaka nwere nnukwu ịba ọcha n'anya.